Network modulation by the subthalamic nucleus in the treatment of Parkinson's disease

摘要: Abstract Deep brain stimulation of the subthalamic nucleus (STN DBS) has become an accepted tool for treatment Parkinson's disease (PD). Although precise mechanism action this intervention is unknown, its effectiveness been attributed to modulation pathological network activity. We examined notion using positron emission tomography (PET) quantify stimulation-induced changes in expression a PD-related covariance pattern (PDRP) regional metabolism. These metabolic were also compared with those observed similar cohort patients undergoing STN lesioning. found that PDRP activity declined significantly (P  findings indicate suppression abnormal feature both and Nonetheless, these two interventions may differ metabolically at level.