Open nanofluidic films with rapid transport and no analyte exchange for ultra-low sample volumes

摘要: Moving to ultra-low ( 500 nL min-1 per square of film; (4) ultra-simple roll-to-roll fabrication; (5) stable and bio-compatible super-hydrophilicity for weeks in air by peptide surface modification. Validation includes both detailed vitro characterization vivo validation with sweat transport from the human skin. Sampling times (skin-to-sensor) <3 min were achieved, setting new benchmarks field wearable sensing. This work addresses significant challenges biosensing, or any other nano-liter regime (<100 nL) fluid sampling sensing application.