Diagnostic Utility of Notch-1 Immunocytochemistry in Endometrial Cytology
作者： Michihiro Mori , Tomoyuki Miyamoto , Setsuyo Ohno , Yasuyuki Miyake , Takuya Sakaguchi
DOI: 10.1159/000335485
关键词:
摘要: Objective: It was the aim of this study to evaluate diagnostic utility Notch-1 immunocytochemistry in distinguishing endometrial glandular and stromal breakdown (EGBD) from adenocarcinoma cytology. Study Design: Samples normal endometrium, EGBD were subjected immunocytochemical staining for Notch-1, we examined labeling index (LI) (the ratio intranuclear Notch-1-positive cells total cells). We compared (1) LI (2) between endometrium adenocarcinoma, (3) adenocarcinoma. Results: In analysis item 1, 32.9 ± 8.4, 19.4 8.2 12.5 7.5% proliferative secretory atrophic respectively. 2, 45.2 7.4%, which significantly higher than that endometrium. 3, 31.3 8.3%, lower Conclusion: conclusion, is a useful method carcinoma
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Anna Bigas, lex Robert-Moreno, Lluis Espinosa, The Notch pathway in the developing hematopoietic system. The International Journal of Developmental Biology. ,vol. 54, pp. 1175- 1188 ,(2010) , 10.1387/IJDB.093049AB
Alex Ferenczy, Pathophysiology of endometrial bleeding. Maturitas. ,vol. 45, pp. 1- 14 ,(2003) , 10.1016/S0378-5122(03)00068-9
Benjamin R. Kipp, Fabiola Medeiros, Michael B. Campion, Tammy J. Distad, Lisa M. Peterson, Gary L. Keeney, Kevin C. Halling, Amy C. Clayton, Direct uterine sampling with the Tao brush sampler using a liquid-based preparation method for the detection of endometrial cancer and atypical hyperplasia: a feasibility study. Cancer. ,vol. 114, pp. 228- 235 ,(2008) , 10.1002/CNCR.23636
Leif W. Ellisen, Jeffrey Bird, Daniel C. West, A.Lee Soreng, Thomas C. Reynolds, Stephen D. Smith, Jeffrey Sklar, TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms Cell. ,vol. 66, pp. 649- 661 ,(1991) , 10.1016/0092-8674(91)90111-B
Anne Wilson, Freddy Radtke, Multiple functions of Notch signaling in self-renewing organs and cancer FEBS Letters. ,vol. 580, pp. 2860- 2868 ,(2006) , 10.1016/J.FEBSLET.2006.03.024
Keiko Shimizu, Yoshiaki Norimatsu, Tadao K. Kobayashi, Masami Sakurai, Seiko Ogura, Akihiko Yoshizawa, Tomoyuki Miyamoto, Yasuyuki Miyake, Yatsuki Aratake, Takuya Sakaguchi, Eiji Ohno, Expression of immunoreactivity and genetic mutation in eosinophilic and ciliated metaplastic changes of endometrial glandular and stromal breakdown: cytodiagnostic implications. Annals of Diagnostic Pathology. ,vol. 13, pp. 89- 95 ,(2009) , 10.1016/J.ANNDIAGPATH.2008.12.007
Jun Watanabe, Yukari Nishimura, Shinpei Tsunoda, Miwa Kawaguchi, Isao Okayasu, Hiroyuki Kuramoto, Liquid-based preparation for endometrial cytology-Usefulness for predicting the prognosis of endometrial carcinoma preoperatively Cancer Cytopathology. ,vol. 117, pp. 254- 263 ,(2009) , 10.1002/CNCY.20035
Yoshiaki Norimatsu, Keiko Shimizu, Tadao K. Kobayashi, Takuya Moriya, Tsunehisa Kaku, Choutatsu Tsukayama, Yasuyuki Miyake, Eiji Ohno, Endometrial glandular and stromal breakdown, part 2: cytomorphology of papillary metaplastic changes. Diagnostic Cytopathology. ,vol. 34, pp. 665- 669 ,(2006) , 10.1002/DC.20512
Michael Reedijk, Silvia Odorcic, Lynn Chang, Hui Zhang, Naomi Miller, David R. McCready, Gina Lockwood, Sean E. Egan, High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Research. ,vol. 65, pp. 8530- 8537 ,(2005) , 10.1158/0008-5472.CAN-05-1069
Kyung Hee Kim, Jin Man Kim, Yoon-La Choi, Young Kee Shin, Ho-chang Lee, In Ock Seong, Bum Kyung Kim, Seoung Wan Chae, Yun-Shin Chung, Seok-Hyung Kim, Expression of Sonic hedgehog signaling molecules in normal, hyperplastic and carcinomatous endometrium Pathology International. ,vol. 59, pp. 279- 287 ,(2009) , 10.1111/J.1440-1827.2009.02366.X