Measures of physical function as risk factors for diabetes mellitus and insulin resistance among HIV-uninfected and HIV-infected men

摘要: Physical activity is an accepted intervention for the prevention of diabetes mellitus (DM) and insulin resistance (IR) in general population. Few studies HIV-infected persons assessed role physical function or as a contributing factor to glucose disorders. The relationship between self-reported performance-based measures individuals has not been assessed. This dissertation examined associations function, DM, IR HIV-uninfected men.Data from 658 men Pitt Meni¦s Study were analyzed assess contribution prevalent DM IR. score (AOR 1.5 per 25 unit decrease, p=0.02) was significantly associated with diabetes, but IR, after adjustment covariates. Data 1790 Multicenter AIDS Cohort (MACS) used risk incident Cumulative incidence highest among low function. Low using more stringent (HR 1.31; 95% CI 1.02-1.66) less 1.29; 1.11-1.50) definitions adjusting BMI, family history race. Among men, definition. To cross-sectional study 2079 MACS conducted. Self-reported correlated weakly. (HIV-uninfected: ƒâ=0.12-0.23, p<0.01; ƒâ=0.16-0.24, p<0.01). had stronger association than men.There are important public health implications this dissertation. two cohorts HIV uninfected men; therefore interventions increase may decrease while simultaneously reducing further disability chronic sequelae already diagnosed diabetes. essential given national burden infection DM.