Quercetin’s Potential to Prevent and Inhibit Oxidative Stress-Induced Liver Cancer
作者： Ming-Ta Sung , Yin-Chiu Chen , Chin-Wen Chi
DOI: 10.1016/B978-0-12-405205-5.00022-2
关键词:
摘要: Hepatocellular carcinoma (HCC) is one of the leading causes cancer-related death in world. Reactive oxygen species (ROS)-induced oxidative stress has been considered a key player development and progression various liver diseases, including viral hepatitis, fibrosis, cirrhosis, cancer (e.g., HCC). In addition to endogenous antioxidants, quercetin available food natural antioxidant protect humans against stress. This protective effect mediated through reducing ROS production, increasing capacity DNA repair, promoting antioxidative responses cells. addition, several studies have found that also an antiproliferation on HCC Moreover, combination treatment with chemotherapeutic drug doxorubicin induced synergistic cytotoxic These results together suggest not only prevent but potential anticancer for treatment.
sci-hub.se 参考文章(60)
Jiuan-Jiuan Hwang, Madhavan P Nair, Ping-Ping H Lee, Ferng-Chun Ke, Lung-Ta Lee, Chithan Kanadaswam, Ming-Ting Lee, Ying-Tang Huang, Blockade of the epidermal growth factor receptor tyrosine kinase activity by quercetin and luteolin leads to growth inhibition and apoptosis of pancreatic tumor cells. Anticancer Research. ,vol. 22, pp. 1615- 1627 ,(2002)
Hong ZHU, Zhenquan JIA, Hara MISRA, Y Robert LI, Oxidative stress and redox signaling mechanisms of alcoholic liver disease: updated experimental and clinical evidence. Journal of Digestive Diseases. ,vol. 13, pp. 133- 142 ,(2012) , 10.1111/J.1751-2980.2011.00569.X
Setsuo Hirohashi, Makoto Nagashima, Hiroshi Kasai, Naohito Yamaguchi, Michiie Sakamoto, Jun Yokota, Ryuya Shimoda, Increased Formation of Oxidative DNA Damage, 8-Hydroxydeoxyguanosine, in Human Livers with Chronic Hepatitis Cancer Research. ,vol. 54, pp. 3171- 3172 ,(1994)
Keiko Taguchi, Hozumi Motohashi, Masayuki Yamamoto, Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution Genes to Cells. ,vol. 16, pp. 123- 140 ,(2011) , 10.1111/J.1365-2443.2010.01473.X
Roger Klein Moreira, None, Hepatic Stellate Cells and Liver Fibrosis Archives of Pathology & Laboratory Medicine. ,vol. 131, pp. 1728- 1734 ,(2007) , 10.1043/1543-2165(2007)131[1728:HSCALF]2.0.CO;2
Lawrence J. Marnett, Oxyradicals and DNA damage Carcinogenesis. ,vol. 21, pp. 361- 370 ,(2000) , 10.1093/CARCIN/21.3.361
Ajay Goel, Ajaikumar B. Kunnumakkara, Bharat B. Aggarwal, Curcumin as “Curecumin”: From kitchen to clinic Biochemical Pharmacology. ,vol. 75, pp. 787- 809 ,(2008) , 10.1016/J.BCP.2007.08.016
Yuh-Fang Chang, Yi-Chiung Hsu, Hui-Fang Hung, Hui-Ju Lee, Wing-Yiu Lui, Chin-Wen Chi, Jane-Jen Wang, Quercetin induces oxidative stress and potentiates the apoptotic action of 2-methoxyestradiol in human hepatoma cells. Nutrition and Cancer. ,vol. 61, pp. 735- 745 ,(2009) , 10.1080/01635580902825571
Hea Jin Park, Ji-Young Lee, Min-Yu Chung, Young-Ki Park, Allyson M. Bower, Sung I. Koo, Charles Giardina, Richard S. Bruno, Green Tea Extract Suppresses NFκB Activation and Inflammatory Responses in Diet-Induced Obese Rats with Nonalcoholic Steatohepatitis Journal of Nutrition. ,vol. 142, pp. 57- 63 ,(2012) , 10.3945/JN.111.148544
Anthony T. Diplock, Defence against reactive oxygen species Free Radical Research. ,vol. 29, pp. 463- 467 ,(1998) , 10.1080/10715769800300521