Diffuse optical spectroscopic imaging of subcutaneous adipose tissue metabolic changes during weight loss

摘要: Changes in subcutaneous adipose tissue (AT) structure and metabolism have been shown to correlate with the development of obesity related metabolic disorders. Measurements AT physiology could provide new insight into disease progression response therapy. An emerging functional imaging technology, diffuse optical spectroscopic (DOSI), was used obtain quantitative measures near infrared (NIR) physiological properties.Ten overweight or obese adults were assessed during 3 months on calorie-restricted diets. DOSI-derived concentrations hemoglobin, water lipid wavelength-dependent scattering amplitude (A) slope (b) obtained from 30 abdominal locations three time points (T0, T6, T12) calculated analyzed using linear mixed-effects models also form 3D surface images.Subjects lost a mean 11.7±3.4% starting weight, while significant changes A (+0.23±0.04 mm(-1), adj. P<0.001),b (-0.17±0.04, P<0.001), fraction (+7.2±1.1%, P<0.001) deoxyhemoglobin (1.1±0.3 μM, observed mixed-effect model analysis.Optical signals reveal alterations that possibly reductions cell volume, hemoglobin dynamics suggest improved perfusion oxygen extraction. These results DOSI measurements NIR properties be enhance understanding role disorders strategies for diagnostic monitoring weight loss.