Use of drugs for nephrolithiasis.

摘要: Renal stone disease often begins by renal colic. In order to manage this event adequately, several goals should be pursued: first, attenuate pain; second, favour progression and spontaneous expulsion of stones; third, prevent from obstructive infectious complications. All the aforementioned points pertain medical management disease. Concerning prevention, it is widely agreed that pathogenesis kidney stones a consequence abnormalities in urine environment, leading disequilibrium between promoters inhibitors crystallization. Therefore, rationale for therapy make less conductive formation, both decreasing state saturation increasing inhibitory potential. only some types stone-forming salts possible obtain undersaturation with solid phase. Indeed, uric acid can chemically dissolved using alkali allopurinol. To lesser extent, also applies cystine stones, use thiols alkali. these subsets, tools are effective new formation. Much more challenging appears treatment calcium containing stones. About 10% such caused systemic disorders and, cases, prevention successfully accomplished curing underlying disease. For instance, parathyroidectomy cures nephrolithiasis case hyperparathyroidism. However, majority patients idiopathic stone-formers, whom metabolic occur, namely, hypercalciuria, hyperoxaluria, hypocitraturia. The correction thiazide diuretics, alkaline citrates, potassium phosphate bisphosphonates based on prevailing defect. Among most recent available tools, Oxalobacter Formigenes probiotics have been proposed treat primary or secondary hyperoxalurias. In general, reduces its recurrence rate, but seldom results stable remission. Anyway, mean reduction need urological procedures associated infective Of course, implies financial efforts, careful cost benefit analysis demonstrates well justified