Periodontal wound healing/regeneration following implantation of recombinant human growth/differentiation factor-5 in a β-tricalcium phosphate carrier into one-wall intrabony defects in dogs

摘要: Lee J-S, Wikesjo UME, Jung U-W, Choi S-H, Pippig S, Siedler M, Kim C-K. Periodontal wound healing/regeneration following implantation of recombinant human growth/differentiation factor-5 in a β-tricalcium phosphate carrier into one-wall intrabony defects dogs. J Clin Periodontol 2010; 37: 382–389. doi: 10.1111/j.1600-051X.2010.01544.x Abstract Objective: Recombinant (rhGDF-5) is being evaluated as candidate therapy support periodontal regeneration. The objective this study was to evaluate the application rhGDF-5 on particulate (β-TCP) using an established defect model. Materials and Methods: Bilateral 4 × 5 mm (width depth), one-wall, critical-size, were surgically created at mandibular second fourth pre-molar teeth 15 Beagle Unilateral five animals received rhGDF-5/β-TCP (Scil Technology GmbH); β-TCP solo; served sham-surgery controls. Contralateral sites treatments reported elsewhere. sacrificed 8-week healing interval for histological examination. Results: Clinical generally uneventful. Sites implanted with exhibited greater enhanced cementum bone formation compared controls; regeneration averaged (± SD) 3.83 ± 0.73 versus 1.65 0.82 2.48 1.28 mm controls (p<0.05). Corresponding values height 3.26 0.30 1.70 0.66 1.68 0.49 mm (p<0.05), area 10.45 2.26 6.31 2.41 3.00 1.97 mm2 Cementum included cellular/acellular or without functionally oriented ligament. A non-specific connective tissue attachment evident control. Controls mostly woven primary osteons, whereas showed noticeable extent lamellar bone. receiving some residual granules apparently undergoing biodegradation obvious differences between sites. alone commonly sequestered fibrovascular marrow. Conclusion: has potential attachment. Long-term studies are necessary confirm uneventful maturation regenerated tissues.