pH-triggered intracellular release of doxorubicin by a poly(glycidyl methacrylate)-based double-shell magnetic nanocarrier.

摘要: Abstract Two core-double-shell pH-sensitive nanocarriers were fabricated using Fe3O4 as magnetic core, poly(glycidyl methacrylate-PEG) and salep dialdehyde the first second shell, doxorubicin hydrophobic anticancer drug. different in drug loading steps. The interaction between shell assumed to be via acetal cross linkages. structure of nanocarriers, organic loading, responsibility, morphology, size, dispersibility, content investigated by IR, NMR, TG, VSM, XRD, DLS, HRTEM UV–Vis analyses. long-term release profiles both showed that before cross-linking led a more nanocarrier exhibiting higher control on DOX release. Cellular toxicity assay (MTT) DOX-free is biocompatible having cell viability greater than 80% for HEK-293 MCF-7 lines. Besides, high cytotoxic effect observed drug-loaded cancer cells. uptake analysis able transport into cytoplasm perinuclear regions In vitro hemolysis coagulation assays demonstrated blood compatibility nanocarrier. results also suggested low concentration have great potential contrast agent resonance imaging (MRI).