Fabrication of continuous electrospun filaments with potential for use as medical fibres

摘要: Soft tissue injuries represent a substantial and growing social economic burden. Medical fibres are commonly used to repair these during surgery. Patient's outcomes are, however, not promising with around 40% of surgical repairs failing within the first few months after surgery due poor regeneration. The application nanofibrous filaments yarns as medical scaffolds has been suggested improve soft regeneration enhance quality repair. However, lack robustness reliability current fabrication methods, continuous cannot be manufactured scaled up in industrial settings currently available for clinical use. We have developed robust automated method that enables manufacture electrospun which potential integrated into existing textile production lines. technology uses wire guide form submicrofibres dense, narrow mesh can detached long thread. thread then stretched create multifilament imitate hierarchical architecture tissues such tendons ligaments. Electrospun polydioxanone produced by this showed improved cellular proliferation adhesion when compared monofilament In vivo, good safety profile mild foreign body reaction complete degradation 5 implantation. These results suggest filament collection become useful platform future textiles.