Journey on Naphthoquinone and Anthraquinone Derivatives: New Insights in Alzheimer's Disease.

摘要: Alzheimer's disease (AD) is a progressive neurodegenerative that characterized by memory loss, cognitive impairment, and functional decline leading to dementia death. AD imposes neuronal death the intricate interplay of different neurochemical factors, which continue inspire medicinal chemist as molecular targets for development new agents treatment with diverse mechanisms action, but also depict more complex scenario. Within wide variety reported molecules, this review summarizes offers global overview recent advancements on naphthoquinone (NQ) anthraquinone (AQ) derivatives whose relevant chemical features structure-activity relationship studies will be discussed view providing perspective design viable drugs AD. In particular, cholinesterases (ChEs), β-amyloid (Aβ) tau proteins have been identified key these classes compounds, where NQ or AQ scaffold may contribute biological effect against main unit significant substructure. The multitarget directed ligand (MTDL) strategy described, chance molecules exhibit potential road therapeutics