Safety studies evaluating the effect of mebendazole on liver function in dogs.

摘要: The effect of repeated and exaggerated mebendazole administration was evaluated in dogs with without experimentally induced altered liver function. Irish Setters Toy Poodles were dosed at 1, 3, 5 times the therapeutic dose (22 mg/kg) for 17 days, any on liver. Mixed breed that received increasing doses 11 to 110 2 months did not show adverse effects remained good health throughout experiment. There substantial evidence carbon tetrachloride-induced changes exacerbated by subsequent treatments 15 dose. Additionally, whose function compromised glutathione depletion microsomal enzyme induction, this same dosage 30 days result hepatotoxic effect. When given prior an hypoxic episode pretreated a barbiturate high protein diet, there no These metabolic manipulations, conjunction administration, failed reveal mechanism hepatic dysfunction associated treatment. Unrecognized factors appear be involved rare cases have been reported after administration. Only careful documentation field further laboratory research can identify these factors.