作者: A. M. Burns , M. P. Shelly , G. R. Park
DOI: 10.2165/00003495-199243040-00007
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摘要: The main aim of sedation in the critically ill patient is to provide relief from anxiety and pain. current, ideal level should leave a who lightly asleep but easily roused. No single regimen suitable for all patients. be monitored, choice agent, dose route administration adjusted appropriately. Midazolam often used sleep anxiolysis. Alternatives include propofol isoflurane. Propofol titrated achieve desired sedation, its effects rapidly end when infusion stopped. Isoflurane also appears promising, special equipment needed administration. Morphine standard analgesic agent. principal metabolites, morphine-6-glucuronide, potent opioid agonist may accumulate renal failure. Of newer agents, alfentanil an agent infusion, Neuromuscular blocking agents are indicated only specific circumstances, once it known patients pain free. actions these unpredictable patient. Alterations drug effect elimination occur, especially with hepatic This apply active metabolites parent drug. When planning regimens, needs staffing levels must remembered. Attention environment important. morphine given by intermittent bolus or mainstay most regimens. short periods care on ICU, during weaning longer acting being eliminated.