Maternal influenza during pregnancy and risk of congenital abnormalities in offspring

摘要: BACKGROUND The teratogenic effect of influenza viruses is currently being debated, and we examined the large population-based data set Hungarian Case-Control Surveillance Congenital Abnormalities (HCCSCA) to study possible association between maternal various congenital abnormalities (CAs). METHODS The 1980–1996 HCCSCA includes 22,843 newborns or fetuses with CAs, 38,151 matched controls (newborn infants without any abnormalities). RESULTS In case group, 1328 (5.8%) mothers had at some time during their pregnancies compared 1838 (4.8%) in control group (adjusted prevalence odds ratios [PORs], 1.3; 95% confidence interval [CI], 1.2–1.4). In calculation adjusted PORs, use antifever drugs employment status were considered. When cases compared, there was a higher second and/or third month pregnancy for cleft lip ± palate POR, 3.2; CI, 2.0–5.3), neural-tube defects 1.9; 1.1–3.3), cardiovascular malformations 1.7; 1.3–2.3). However, direct from appears be unlikely, suggest that CAs indicated above can explained mainly by fever, because this risk reduced drugs. Periconceptional folic acid supplementation also showed preventive these CAs. CONCLUSIONS The indirect may restricted appropriate medical treatment (e.g., drugs) periconceptional supplementation. Birth Defects Research (Part A), 2005. © 2005 Wiley-Liss, Inc.