Restoration of Mal overcomes the defects of apoptosis in lung cancer cells
作者： Li-Tao Yang , Fei Ma , Hao-Tao Zeng , Miao Zhao , Xian-Hai Zeng
DOI: 10.1371/JOURNAL.PONE.0227634
关键词:
摘要: Background and aims Cancer is one of the life-threatening diseases human beings; pathogenesis cancer remains to be further investigated. Toll like receptor (TLR) activities are involved in apoptosis regulation. This study elucidate role Mal (MyD88-adapter-like) molecule regulation lung (LC) cells. Methods The LC tissues were collected from patients. cells normal control (NC) isolated analyzed by pertinent biochemical immunological approaches. Results We found that fewer apoptotic induced cisplatin culture as compared NC expression Fas ligand (FasL) was lower than FasL mRNA levels declined spontaneously A complex FasL/TDP-43 detected expressed less Activation lipopolysaccharide (LPS) increased TDP-43 formed a with prevent decay. Reconstitution or restored sensitiveness inducers. Conclusions express low contributes decay through impairing expression. restores inducers may novel therapeutic approach for treatment.
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