Relative Efficacy of Drugs for the Treatment of Sleepiness in Narcolepsy
作者： Merrill M. Mitler , Roza Hajdukovic
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摘要: A survey was conducted on 10 polysomnographic studies the pharmacologic treatment of sleepiness narcolepsy. Three employed MSLT and 7 MWT as their polygraphic measure sleep tendency. Statistically clinically significant therapeutic changes were apparent for pemoline, modafinil, dextroamphetamine methylphenidate. Codeine, ritanserin protriptyline did show statistically effects. The common feature among drugs that produce improvements seems to be facilitatory action central catecholaminergic transmission. Within this group drugs, only methylphenidate brought latencies approximately 70% normal levels.
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