Regional cerebral blood flow in acute experimental allergic encephalomyelitis

摘要: Abstract Regional cerebral blood flow was studied in Lewis rats witfulminant acute experimental allergic encephalomyelitis (EAE). [ 14 C iodoantipyrine used as a tracer. By employing short time and an infusion schedule producing increasing arterial tracer concentration, the spatial resolution of method fine enougto detect focal increases small central nervous system lesions (lymphocytic accumulations). An increase 100% decrease 50% cortex EAE animals statistically significant. In all other regions (deep structures, cerebellum), did not differ from control values. The corresponding to may be due inflammatory hyperemia. cortical secondary sensory motor impairment.