Moderate additive immunosuppressive effect of thalidomide combined with cyclosporin A in rat cardiac transplantation

摘要: halidomide is an immunomodulating agent shown to prolong graft survival in experimental skin, renal, cardiac and bone marrow transplantation. The main purpose of the present study was investigate possible additive effect combining thalidomide with cyclosporin A (CyA). Members our group have previously created a bsis for such studies by demonstrating ability Linomide abolish CyA. additional combined treatment second drug thereby more readily evaluated, compared using subtherapeutic dose levels induce early rejection. Cardiac grafting performed three rat strain combinations (BN WF, DA Lew, BN Lew). Rats were given no treatment, or thalidomide, CyA and/or single, double triple therapy. Except consistent beneficial as single varied depending on combination used. In Lew combination, expected effects seen, significantly (P = 0.004) when added Linomide. However, there alone. WF recipients hearts, tended 0.07), surprisingly manifested marked immunosuppressive 0.0002) did not counteract When transplanting grafts recipients, reduced but completely Neither nor had any impact their own. To sum up, minimal moderate that two drugs, Linomide, used, similar respect prolongation used grafting, fact which may indicate them mechanism action, both having been exert tumour necrosis factor α.