Genomic characteristics of pancreatic squamous cell carcinoma, an investigation by using high throughput sequencing after in-solution hybrid capture.

摘要: Squamous cell carcinoma (SCC) of pancreas is a rare histotype pancreatic ductal which distinct from adenocarcinoma (AC). Although there are standard treatments for AC, no precise therapies exist SCC. Here, we screened 1033 cases cancer and identified 2 pure SCC, were pathologically diagnosed on the basis finding definite intercellular bridges and/or focal keratin peal formation in tumor cells. Immunohistochemistry assay confirmed positive expression CK5/6 p63 To verify genomic characteristics employed in-solution hybrid capture targeting 137 cancer-related genes accompanied by high throughput sequencing (HTS) to compare different genetic variants SCC AC pancreas. We compared alterations known biomarkers tissues, nine mutated pancreas: C7orf70, DNHD1, KPRP, MDM4, MUC6, OR51Q1, PTPRD, TCF4, TET2, (ABCB1, CSF1R, CYP2C18, FBXW7, ITPA, KIAA0748, SOD2, SULT1A2, ZNF142) that AC. This study may have taken one step forward discovery potential targeted treatment