Serum fibrosis markers can predict rapid fibrosis progression after liver transplantation for hepatitis C

摘要: Although recurrent hepatitis C virus (HCV) after liver transplantation (LT) is universal, a minority of patients will develop cirrhosis within 5 years surgery, which places them at risk for allograft failure. This retrospective study investigated whether 2 serum fibrosis markers, hyaluronic acid (HA) and YKL-40, could be used to predict rapid progression (RFP) post-LT. These markers were compared with conventional laboratory tests, histological assessment, hepatic stellate cell activity (HSCA), key step in fibrogenesis, as assessed by immunohistochemical staining alpha-smooth muscle actin. Serum protocol biopsy samples obtained from 46 LT recipients means +/- (biopsy 1) 39 6 2) months post-LT, respectively. RFP was defined an increase the score >or= 1 (a mean interval 33 months). The ability parameters areas under receiver operating characteristic curves (AUROCs). Of subjects, 15 developed RFP. HA YKL-40 performed significantly better than HSCA predicting post-LT HCV 1, AUROCs 0.89 0.92, accuracy 90 microg/L 200 80% 96%, In conclusion, we found that elevated levels first accurately predicted Larger studies evaluating role management are warranted.