Lipid transport in Mycobacterium tuberculosis and its implications in virulence and drug development.

摘要: Tuberculosis is still a major health problem worldwide and one of the main causes death by single infectious agent. Only few drugs are really effective to treat tuberculosis, hence, emergence multiple, extensively, totally drug resistant bacilli compromises already difficult antituberculosis treatments. Given persistent global burden it crucial understand underlying mechanisms required for pathogenicity Mycobacterium tuberculosis (Mtb), causal agent in order pave way developing better strategies prevent tuberculosis. The exclusive mycobacterial cell wall lipids such as trehalose monomycolate dimycolate (TMM, TDM), phthiocerol dimycocerosate (PDIM), sulpholipid-1 (SL-1), diacyl (DAT), pentacyl (PAT), among others, known play an important role pathogenesis; thus, proteins responsible their transport potential virulence factors. MmpL MmpS mediate across membrane. In Mtb, MmpL3, MmpL7 MmpL8 TMM, PDIM SL-1 respectively. translocation DAT biosynthesis PAT likely due MmpL10. involved other processes efflux (MmpL5 MmpL7), siderophore export (MmpL4/MmpS4 MmpL5/MmpS5), heme uptake (MmpL3 MmpL11). Altogether, these can be regarded new targets development. We will review recent advances inhibitors proteins, challenging context targeting membrane future prospects candidates.