Non-coding RNAs: key players in cardiac disease.
作者： Fabian Philipp Kreutzer , Jan Fiedler , Thomas Thum
DOI: 10.1113/JP278131
关键词:
摘要: Molecular mechanisms underlying heart failure (HF) are only partly understood. Non-coding RNAs (ncRNAs) have been reported to control function and signalling routes in the myocardium. As ncRNAs such as microRNAs (miRNAs), long non-coding (lncRNAs) or circular (circRNAs) can be selectively targeted via pharmacological approaches, this opens new avenues for diagnostic therapeutic approaches. Here, we review main ncRNA classes how they influence cardiac biology. In addition provide insight into role of chemotherapy-induced dysfunction. To a better understanding cardiovascular biology present an outlook on specialized functions chromatin remodelling, biomarker potential recently discovered ncRNA-derived micropeptides.
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