Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats.

摘要: Thymoquinone (TQ) is the major active compound derived from Nigella sativa. Our aim of this work was to evaluate antioxidant and antiarthritic activity TQ in Wistar rat by collagen induced arthritis (CIA). administered at a dose 5mgkg(-1) body weight once daily for 21days. The effects treatment rats were assessed biochemical (articular elastase, MPO, LPO, GSH, catalase, SOD NO), inflammatory mediators (IL-1β, IL-6, TNF-α, IL-10, IFN-γ PGE(2)) histological studies joints. effective bringing significant changes on all parameters NO) studied. Oral administration resulted significantly reduced levels pro-inflammatory increased level IL-10. protective against RA also evident decrease scoring bone histology. In conclusion, fact that abolished number factors known be involved pathogenesis indicates thymoquinone may have potential value disease.