摘要: This chapter focuses on purinergic neurotransmission and nucleotide receptors. The proportions of ATP noradrenaline (NA) vary in different tissues species, during development ageing pathophysiological conditions. Acetylcholine (ACh) are cotransmitters parasympathetic nerves supplying the urinary bladder. Purinergic signaling brain stem is involved control autonomic functions, including cardiovascular respiratory regulation hormone secretion body temperature at hypothalamic level. nucleus tractus solitarius (NTS) a major integrative center reflex system; stimulation P2X receptors NTS evokes hypotension. Adenoviral expression P2X1 receptor-green fluorescent protein construct vas deferens shows receptor to be localized clusters, with larger ones apposing nerve varicosities. formation oligomers by P2Y likely widespread greatly increase diversity signaling. often expressed same cells as Thus, there possibility bidirectional cross-talk between these two families nucleotide-sensitive © 2012 Elsevier Inc. All rights reserved.
sci-hub.se 参考文章(24)
Geoffrey Burnstock, Gillian E. Knight, Cellular distribution and functions of P2 receptor subtypes in different systems International Review of Cytology-a Survey of Cell Biology. ,vol. 240, pp. 31- 304 ,(2004) , 10.1016/S0074-7696(04)40002-3
G Burnstock, A Verkhratsky, Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death Cell Death and Disease. ,vol. 1, ,(2010) , 10.1038/CDDIS.2009.11
G. BURNSTOCK, H. WONG, Comparison of the effects of ultraviolet light and purinergic nerve stimulation on the guinea-pig taenia coli. British Journal of Pharmacology. ,vol. 62, pp. 293- 302 ,(1978) , 10.1111/J.1476-5381.1978.TB08459.X
Eric A. Barnard, Geoffrey Burnstock, Tania E. Webb, G protein-coupled receptors for ATP and other nucleotides: a new receptor family Trends in Pharmacological Sciences. ,vol. 15, pp. 67- 70 ,(1994) , 10.1016/0165-6147(94)90280-1
G. Burnstock, Purine and pyrimidine receptors Cellular and Molecular Life Sciences. ,vol. 64, pp. 1471- 1483 ,(2007) , 10.1007/S00018-007-6497-0
Anthony J. Brake, Michael J. Wagenbach, David Julius, New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor Nature. ,vol. 371, pp. 519- 523 ,(1994) , 10.1038/371519A0
G. BURNSTOCK, G. CAMPBELL, D. SATCHELL, ANNE SMYTHE, Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut British Journal of Pharmacology. ,vol. 120, pp. 337- 357 ,(1997) , 10.1111/J.1476-5381.1997.TB06815.X
G. BURNSTOCK, The changing face of autonomic neurotransmission. Acta Physiologica Scandinavica. ,vol. 126, pp. 67- 91 ,(1986) , 10.1111/J.1748-1716.1986.TB07790.X
Geoffrey Burnstock, Do some nerve cells release more than one transmitter Neuroscience. ,vol. 1, pp. 239- 248 ,(1976) , 10.1016/0306-4522(76)90054-3
P. Sneddon, G. Burnstock, Inhibition of excitatory junction potentials in guinea-pig vas deferens by α, β-methylene-ATP: Further evidence for ATP and noradrenaline as cotransmitters European Journal of Pharmacology. ,vol. 100, pp. 85- 90 ,(1984) , 10.1016/0014-2999(84)90318-2