Concepts of immunotherapy for glioma

摘要: Immunotherapy is coming to the fore as a viable anti-cancer treatment modality, even in poorly immunogenic cancers such glioblastoma (GBM). Accumulating evidence suggests that central nervous system may not be impervious tumor-specific immune cells and could an adequate substrate for immunologic therapies. Recent advances antigen-specific cancer vaccines checkpoint blockade GBM provide promise future immunotherapy glioma. As anti-GBM immunotherapeutics enter clinical trials, it important understand interactions, if any, between immune-based modalities current standard of care involving chemoradiation steroid therapy. Current data preclude success immunotherapeutics, their effects synergistic. The therapy lies power combination modalities, care.