Characterization of Acute and Chronic Hepatitis B Virus Genotypes in Canada.
作者： Carla Osiowy , Elizabeth Giles , Max Trubnikov , Yogesh Choudhri , Anton Andonov
DOI: 10.1371/JOURNAL.PONE.0136074
关键词:
摘要: Objective The prevalence and distribution of hepatitis B virus (HBV) genotypes in Canada is not known. Genotypic analysis may contribute to a better understanding HBV strain transmission risk. Methods HBV surface antigen (HBsAg) positive samples acute (n = 152) chronic 1533) submitted for or reference genotype testing between 2006 2012 were analyzed. The HBsAg coding region was amplified determine the by INNO-LiPA assay sequence analysis. Single multivariate analyses used describe genotypes’ associations with known demographic behavioral risk factors 126 linked cases HBV. Results Nine detected (A I), including mixed infections. Genotype C (HBV/C) dominated within infections while HBV/D A prevailed among cases. History incarceration residing carrier injection drug user most frequently reported risks infection. Over time, HBV/A increased both infections, HBV/C decreased infections. Conclusion Chronic differ relative their factors, suggesting different routes clinical progression
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