Age-Dependent Effect of Transcranial Alternating Current Stimulation on Motor Skill Consolidation.
作者： Shane Fresnoza , Monica Christova , Lara Bieler , Christof Körner , Ulrike Zimmer
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摘要: Transcranial alternating current stimulation (tACS) is the application of subthreshold, sinusoidal to modulate ongoing brain rhythms related sensory, motor and cognitive processes. Electrophysiological studies suggested that effect tACS applied at an alpha frequency (8-12 Hz) was state-dependent. The effects tACS, is, increase in parieto-occipital electroencephalography (EEG) power magnetoencephalography (MEG) phase coherence, only observed when eyes were open (low power) not closed (high power). This state-dependency might extend aging characterized by general slowing decrease spectral rhythm. We additionally hypothesized will influence cortex, which involved skill learning consolidation. A group young old healthy adults performed a serial reaction time task (SRTT) with their right hand before after stimulation. Each participant underwent three sessions stimulation: sham, individual participant's peak or (iAPF; α-tACS) iAPF plus 2 Hz (α2-tACS) left cortex for 10 min (1.5 mA). measured on (GMS) sequence-specific (SS) found α-tACS α2-tACS improved GMS SS consolidation group. In contrast, minimally but impaired On other hand, detrimental both skills Our results suggest individuals aberrant rhythm such as elderly could benefit more from stimulation, whereas intact be detrimental.
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