Cocaine Metabolism in Humans after Use of Alcohol Clinical and Research Implications

摘要: The simultaneous administration of cocaine and alcohol implies a pharmacological interaction at pharmacodynamic pharmacokinetic levels. latter involves an alteration kinetics metabolism, as well the biosynthesis newly active metabolites, such cocaethylene. Cocaethylene is metabolized along same pathways cocaine. Its detection in biological samples indicates combined consumption alcohol. From epidemiological toxicological data, it has been suggested that combination produces increased toxicity addition to behavioral changes. There some debate regarding contribution cocaethylene this rise toxicity. profile very similar During both substances, plasma concentrations can explain many cardiovascular effects observed. probably minor; s are likely additive those Perhaps its longer elimination half-life help understanding long-lasting alcohol-cocaine combination.