Paraoxonase 1 (PON1)-L55M among common variants in the coding region of the paraoxonase gene family may contribute to the glycemic control in type 2 diabetes.
作者： Abdolkarim Mahrooz , Mohammad Bagher Hashemi-Soteh , Masoud Heydari , Ruzbeh Boorank , Fatemeh Ramazani
DOI: 10.1016/J.CCA.2018.05.037
关键词:
摘要: Abstract Objective Genome studies have shown that the genes encoding paraoxonase 1 (PON1) and PON2 are associated with glucose metabolism. The goal of this study was to simultaneously evaluate association between functional variants in PON1 susceptibility for type 2 diabetes (T2D) determine whether they can affect glycemic control. Methods We performed a case-control 145 newly diagnosed patients T2D 148 controls. common including PON1-Q192R, PON1-L55M PON2-S311C were genotyped by PCR-based RFLP. A mismatch-PCR/RFLP applied genotyping PON2-A148G variant. Results variant PON1-Q192R males (OR = 2.55, 95%CI 1.16–5.69, p = 0.023) females (OR = 1.56, 1.00–2.44, p = 0.059) T2D. Compared LL genotypes PON1-L55M, HbA1c levels significantly lower LM (p = 0.01) MM (p = 0.032) patients. Multiple linear regression analyses showed among only as an independent variable This influenced control poor so it better following order: LL Conclusions Sex should be considered confounding on Patients sharing 55 M allele prone having good Our findings provide genetic evidence may factor contributing
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