Considerations in the Design and Analysis of Chronic Aquatic Tests of Toxicity

摘要: Some considerations in the planning of toxicity tests and reporting results are discussed. The need for using standardized stocks fish data recording procedures is argued. Standardized sheets hatchability presented as an example a number developed by authors. We consider aspects statistical analysis arising from aquatic tests. discussion emphasizes analyses displays interpretation qualitative mortality abnormality data, but ideas pertain also to other types data. techniques discussed include preliminary graphical displays, homogeneity among tanks within treatment groups, adjustments account tank-to-tank heterogeneity outlier detection procedures, overall effects, multiple comparisons pairwise confidence intervals groups with control group, dose-response curve fitting associated estimates "safe concentrations."