Evidence that the nonsense-mediated mRNA decay pathway participates in X chromosome dosage compensation in mammals

摘要: Current models of X chromosome dosage compensation are usually framed by reference to how regulation in transcriptional level elevates the gene expression active chromosome. This framework, however, might be oversimplified because can also act at post-transcriptional level. Here, after a genome-wide survey, we find that autosomal genes more likely subject nonsense-mediated mRNA decay (NMD) than X-linked genes. Furthermore, demonstrate NMD inhibition, balanced between and autosomes is corrupted such global mean X/autosome ratio decreased 10-15%. Our results identify as post-transcription-level regulatory mechanism contributes observed fine-tuning mammals.