Genomic organization and promoter characterization of human CXCR4 gene1
作者： A. Caruz , M. Samsom , J.M. Alonso , J. Alcami , F. Baleux
DOI: 10.1016/S0014-5793(98)00359-7
关键词:
摘要: CXCR4 is the receptor for CXC chemokine SDF1 that has essential functions on embryo organogenesis, immunological and T lymphocyte trafficking. Recently, drawn unexpected attention as it was recently identified a co-factor required entry of lymphotropic HIV isolates in CD4+ lymphocytes. only so far. This suggests expression critical biological effects SDF1. To investigate mechanisms controlling both constitutive induced receptors we have isolated characterized promoter region determined genomic structure human gene. The gene contains two exons separated by an intronic sequence. A 2.6 kb 5′-flanking located upstream open reading frame TATA box transcription start site characteristic functional promoter. also putative consensus binding sequences different factors, some them associated with hemopoiesis development.
ulb.ac.be
elsevier.com
sci-hub.se 参考文章(28)
M. Loetscher, T. Geiser, T. O'Reilly, R. Zwahlen, M. Baggiolini, B. Moser, Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes. Journal of Biological Chemistry. ,vol. 269, pp. 232- 237 ,(1994) , 10.1016/S0021-9258(17)42339-8
M Heesen, M E Dorf, N P Gerard, M A Berman, U E Höpken, Alternate splicing of mouse fusin/CXC chemokine receptor-4: stromal cell-derived factor-1alpha is a ligand for both CXC chemokine receptor-4 isoforms. Journal of Immunology. ,vol. 158, pp. 3561- 3564 ,(1997)
J. Alcamí, T. Laín de Lera, L. Folgueira, M.A. Pedraza, J.M. Jacqué, F. Bachelerie, A.R. Noriega, R.T. Hay, D. Harrich, R.B. Gaynor, Absolute dependence on kappa B responsive elements for initiation and Tat‐mediated amplification of HIV transcription in blood CD4 T lymphocytes. The EMBO Journal. ,vol. 14, pp. 1552- 1560 ,(1995) , 10.1002/J.1460-2075.1995.TB07141.X
Marco Baggiolini, Beatrice Dewald, Bernhard Moser, Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines. Advances in Immunology. ,vol. 55, pp. 97- 179 ,(1994) , 10.1016/S0065-2776(08)60509-X
Takashi Uchiyama, Toshiyuki Hori, Osamu Yoshie, Akihiko Sato, Hitoshi Sakaida, Hisatoshi Shida, Toshihiro Nakajima, Detection and Delineation of CXCR-4 (Fusin) as an Entry and Fusion Cofactor for T Cell-Tropic HIV-1 by Three Different Monoclonal Antibodies Journal of Immunology. ,vol. 160, pp. 180- 188 ,(1998)
Conrad C. Bleul, Michael Farzan, Hyeryun Choe, Cristina Parolin, Ian Clark-Lewis, Joseph Sodroski, Timothy A. Springer, The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature. ,vol. 382, pp. 829- 833 ,(1996) , 10.1038/382829A0
James J Campbell, Joseph Hedrick, Albert Zlotnik, Michael A Siani, Darren A Thompson, Eugene C Butcher, Chemokines and the Arrest of Lymphocytes Rolling Under Flow Conditions Science. ,vol. 279, pp. 381- 384 ,(1998) , 10.1126/SCIENCE.279.5349.381
S. A. Omori, R. Wall, Multiple motifs regulate the B-cell-specific promoter of the B29 gene Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 11723- 11727 ,(1993) , 10.1073/PNAS.90.24.11723
C. C. Bleul, L. Wu, J. A. Hoxie, T. A. Springer, C. R. Mackay, The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 1925- 1930 ,(1997) , 10.1073/PNAS.94.5.1925
Y. Feng, C. C. Broder, P. E. Kennedy, E. A. Berger, HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor Science. ,vol. 272, pp. 872- 877 ,(1996) , 10.1126/SCIENCE.272.5263.872