HMG-CoA reductase inhibitor stabilizes rabbit atheroma by increasing basal NO and decreasing superoxide.
作者： Navin Kumar Thakur , Toshio Hayashi , Daigo Sumi , Hatsuyo Kano , Taku Tsunekawa
DOI: 10.1152/AJPHEART.2001.281.1.H75
关键词:
摘要: Male rabbits fed a 0.5% cholesterol diet for 8 wk were divided into three groups. Group 1 was hypercholesterolemic; group 2 regular an additional 12 wk; and 3 with simvastatin (5 mg x kg(-1) day(-1)). Simvastatin treatment reduced the atherosclerotic area total esterified concentrations in thoracic aorta. Tone-related basal nitric oxide (NO) release highest 3. Acetylcholine-induced, NO-dependent relaxation improved compared 2. Amount of endothelial synthase (eNOS) mRNA vessels increased 1, normal aorta, decreased 2; however, it did not decrease The amount O released from rabbits; 3, especially cells. Peroxynitrite determined by nitrotyrosine staining Additionally, arteries or without investigated. aorta simvastatin-treated showed increase tone-related NO eNOS release. Taken together, upregulation observed vivo process sufficient stabilization atheroma following simvastatin.
sci-hub.se 参考文章(35)
Andreas Tobler, H. Phillip Koeffler, Myeloperoxidase: Localization, Structure, and Function Blood Cell Biochemistry. pp. 255- 288 ,(1991) , 10.1007/978-1-4615-3796-0_10
A Cudd, I Fridovich, Electrostatic interactions in the reaction mechanism of bovine erythrocyte superoxide dismutase. Journal of Biological Chemistry. ,vol. 257, pp. 11443- 11447 ,(1982) , 10.1016/S0021-9258(18)33779-7
J M Griscavage, M P Sherman, N E Rogers, L J Ignarro, Inducible nitric oxide synthase from a rat alveolar macrophage cell line is inhibited by nitric oxide. Journal of Immunology. ,vol. 151, pp. 6329- 6337 ,(1993)
J. S. Beckman, W. H. Koppenol, Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. American Journal of Physiology-cell Physiology. ,vol. 271, ,(1996) , 10.1152/AJPCELL.1996.271.5.C1424
K H Benzuly, R C Padgett, S Kaul, D J Piegors, M L Armstrong, D D Heistad, Functional improvement precedes structural regression of atherosclerosis. Circulation. ,vol. 89, pp. 1810- 1818 ,(1994) , 10.1161/01.CIR.89.4.1810
Charles C Allain, Lucy S Poon, Cicely S G Chan, W Richmond, Paul C Fu, Enzymatic determination of total serum cholesterol. Clinical Chemistry. ,vol. 20, pp. 470- 475 ,(1974) , 10.1093/CLINCHEM/20.4.470
T. Hayashi, J. M. Fukuto, L. J. Ignarro, G. Chaudhuri, Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis Proceedings of the National Academy of Sciences of the United States of America. ,vol. 89, pp. 11259- 11263 ,(1992) , 10.1073/PNAS.89.23.11259
Abraham A. Kroon, Wim R.M. Aengevaeren, Tjeerd van der Werf, Gerard J.H. Uijen, Johan H.C. Reiber, Albert V.G. Bruschke, Anton F.H. Stalenhoef, LDL-Apheresis Atherosclerosis Regression Study (LAARS) Effect of Aggressive Versus Conventional Lipid Lowering Treatment on Coronary Atherosclerosis Circulation. ,vol. 93, pp. 1826- 1835 ,(1996) , 10.1161/01.CIR.93.10.1826
Dimitris Tousoulis, Graham Davies, Tom Crake, David C. Lefroy, Stuart Rosen, Attilio Maseri, Angiographic characteristics of infarct-related and non-infarct-related stenoses in patients in whom stable angina progressed to acute myocardial infarction American Heart Journal. ,vol. 136, pp. 382- 388 ,(1998) , 10.1016/S0002-8703(98)70210-8
Bonnie H. Weiner, Ira S. Ockene, Peter H. Levine, Henri F. Cuénoud, Marc Fisher, Brian F. Johnson, Assaad S. Daoud, John Jarmolych, David Hosmer, Mark H. Johnson, Anita Natale, Christine Vaudreuil, James J. Hoogasian, Inhibition of Atherosclerosis by Cod-Liver Oil in a Hyperlipidemic Swine Model New England Journal of Medicine. ,vol. 315, pp. 841- 846 ,(1986) , 10.1056/NEJM198610023151401