The Influence of Excessive IL-6 Production In Vivo on the Development and Function of Foxp3+ Regulatory T Cells
作者： Minoru Fujimoto , Mayumi Nakano , Fumitaka Terabe , Hirohisa Kawahata , Tomoharu Ohkawara
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摘要: IL-6 is a proinflammatory cytokine and its overproduction implicated in variety of inflammatory disorders. Recent vitro analyses suggest that key determines the balance between Foxp3(+) regulatory T cells (Tregs) Th17 cells. However, it remains unclear whether excessive production vivo alters development function Tregs. In this study, we analyzed transgenic (Tg) mice which serum levels are constitutively elevated. Interestingly, Tg mice, whereas peripheral lymphoid organs were enlarged, exhibited activated phenotype, Tregs not reduced but rather increased compared with wild-type mice. addition, from normally suppressed proliferation naive vitro. Furthermore, cotransferred CD4 into SCID-IL-6 inhibited colitis as successfully those transferred control SCID These results indicate does inhibit or vivo. when alone transferred, retrieved Moreover, Helios(-) subpopulation Tregs, recently defined extrathymic was significantly Collectively, these overproduced inhibits inducible Treg generation cells, affect natural
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