Practical synthesis, anticonvulsant, and antimicrobial activity of N-allyl and N-propargyl di(indolyl)indolin-2-ones
作者： Chandrasekaran Praveen , Asairajan Ayyanar , Paramasivan Thirumalai Perumal
DOI: 10.1016/J.BMCL.2011.04.117
关键词:
摘要: An operation friendly protocol for the synthesis of novel di(indolyl)indolin-2-ones via Cu(OTf)(2) catalyzed bis-addition N-allyl and N-propargyl indole with isatin was developed. This methodology allowed us to achieve products in excellent yields without requiring purification technique like column chromatography. All synthesized compounds were evaluated their vivo anticonvulsant activity against maximal electroshock test. Six showed maximum compared standard drug phenytoin. The scope new molecules as antimicrobial agents tested two bacterial strains (Staphylococcus aureus Escherichia coli) one fungal strain (Candida albicans).
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