Dynamic interactions between RNA viruses and human hosts unravelled by a decade of next generation sequencing.

摘要: Abstract Background Next generation sequencing (NGS) methods have significantly contributed to a paradigm shift in genomic research for nearly decade now. These been useful studying the dynamic interactions between RNA viruses and human hosts. Scope of review In this review, we summarise discuss key applications NGS host – pathogen viral infections humans with examples. Major conclusions Use study globally relevant revolutionized our understanding within evolution these viruses. also clinical decision-making guiding biomedical on vaccine design. General significance has instrumental studies resolving within-host variants distribution nucleotide polymorphisms along full-length genomes high throughput, cost effective manner. future, novel advances such as long read, single molecule simultaneous pathogens may become standard practice settings. This will bring new challenges big data analysis.