Interaction of the rostral basolateral amygdala and prelimbic prefrontal cortex in regulating reinstatement of cocaine-seeking behavior.

摘要: Previous findings in rats suggest that the rostral basolateral amygdala (rBLA) and prelimbic prefrontal cortex (plPFC) are likely components of cue reinstatement circuitry based on bilateral inactivation each site alone. In present investigation, we examined whether rBLA plPFC interact to regulate cocaine-seeking behavior elicited by reexposure a combination discrete contextual cocaine-paired cues. After establishing stable baseline responding under second-order schedule cocaine reinforcement presentation, underwent response-extinction training which cues were withheld. To test interaction, with asymmetric cannulae placements received vehicle or lidocaine infusions prior testing during presented, absence availability, schedule. Asymmetric significantly attenuated relative treatment. As expected, unilateral did not disrupt Findings propose critical intrahemispheric interaction between regulating drug-paired