Acute urinary morbidity following I-125 interstitial implantation of the prostate gland

摘要: The objective of this paper was to evaluate the acute urinary morbidity associated with I-125 interstitial implantation prostate gland. From 1991–1995, 117 patients underwent ultrasound (U/S)-guided Median dose 90% gland (d90) 14.68 Gy (range = 1.65–21.75 Gy). patients' symptoms were recorded pre-implantation and at regular intervals after using International Prostate Symptom Score (IPSS), a self-assessment questionnaire in which scored 7 symptoms: incomplete emptying, frequency, intermittency, urgency, weak stream, straining, nocturia. follow-up 12 months. natural history implant-related assessed manner. In addition, dosimetric factors including U/S volume, total activity, activity per seed, volume histogram (DVH) values for gland, area (DAH) urethra bladder examined correlation severity each symptom as well IPSS (sum individual scores). Total peaked 1 month post-implant gradually returned approximately baseline 24 directly correlated DVH prostate. IPSS, however, did not correlate or urethral DAH. With exception bladder, urethra. Frequency scores did, only but also side effects are transient peak post-implant. irritative developed closely related Urethral appears affect frequency most significantly. Urinary symptoms, therefore, may be limiting factor when considering escalation I-125. Radiat. Oncol. Invest. 6:135–141, 1998. © 1998 Wiley-Liss, Inc.