Evaluation of maternal serum dimeric inhibin a as a first‐trimester marker of down's syndrome
作者： E. M. Wallace , V. E. Grant , I. A. Swanston , N. P. Groome
关键词:
摘要: While second-trimester prenatal screening programmes for Down's syndrome have become established in care, it would be advantageous to able offer earlier preganancy. To this end, we evaluated a new potential maternal serum marker, dimeric inhibin A, as possible first-trimester marker. Dimeric A was measured propsectively collected from 23 cases of and matched chromosomally normal controls, at 11–13 weeks' gestation. Levels protein were significantly elevated the pregnancies compared with control pregnancies. The median multiple (MOM) samples 2.46 (95 per cent confidence interval: 2.11–3.26, P<0.0001 vs. controls). These results suggest that is useful discriminator Down's-affected first trimester sensitive combination age other markers may practicable trimester.
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