Multivalent glycoconjugate syntheses and applications using aromatic scaffolds

摘要: Glycan–protein interactions are of utmost importance in several biological phenomena. Although the variety carbohydrate residues mammalian cells is limited to less than a dozen different sugars, their spatial topographical presentation what now associated as “glycocodes” provides fundamental keys for specific and high affinity “lock-in” recognition events with wide range pathologies. Toward deciphering our understanding these glycocodes, chemists have developed new creative tools that included dendrimer chemistry order provide monodisperse multivalent glycoconjugates. This review survey numerous aromatic architectures generated relevant carbohydrates using covalent attachment or supramolecular self-assemblies. The basic concepts toward controlled syntheses will be described modern synthetic procedures particular emphasis on powerful organometallic methodologies. large dendritic scaffolds, together brief unique biophysical properties critically reviewed. distinctiveness resulting glycoarchitectures, encompassing glycoclusters, glycodendrimers molecularly defined self-assemblies, forming well organized cross-linked lattices binding proteins (lectins) photophysical, medical, imaging also briefly highlighted. topic presented increasing backbone complexities end fullerenes self-assembled nanostructures, thus complementing various scaffolds this special thematic issue dedicated glycoscience.