One-Pot Synthesis and Evaluation of Antileishmanial Activities of Functionalized S-Alkyl/Aryl Benzothiazole-2-carbothioate Scaffold.

摘要: The synthesis of hitherto unreported S-alkyl/aryl benzothiazole-2-carbothioate is reported from thiols, oxalyl chloride, and 2-aminothiophenols using 10 mol % n-tetrabutylammonium iodide (TBAI) as catalyst in acetonitrile through multicomponent reaction (MCR) strategy. present protocol favored formation benzothiazoles thioesters via simultaneous C–N C–S bonds good yields with a wide range substrates. A few the synthesized derivatives were evaluated for their antimicrobial activity against protozoan parasite Leishmania donovani, causative agent visceral leishmaniasis (VL). Further, these compounds displayed no toxicity toward macrophage RAW 264.7 cells are therefore nontoxic effective antileishmanial leads. In silico docking studies performed to understand possible binding site interaction trypanothione reductase (TryR).