Proteasomes from Structure to Function: Perspectives from Archaea

摘要: Insight into the world of proteolysis has expanded considerably over past decade. Energy‐dependent proteases, such as proteasome, are no longer viewed nonspecific degradative enzymes associated solely with protein catabolism but intimately involved in controlling biological processes that span life to death. The proteasome maintains this exquisite control by catalyzing precisely timed and rapid turnover key regulatory proteins. Proteasomes also interplay chaperones ensure quality readjust composition proteome following stress. Archaea encode proteasomes highly related those eukaryotes basic structure function. Investigations archaeal coupled greatly facilitated our understanding molecular mechanisms govern regulated degradation elaborate nanocompartmentalized machine.