Studies on the Phosphorylation of Cytosine Arabinoside in Mammalian Cells

摘要: The effect of cytosine arabinoside 59-triphosphate (araCTP) on the phosphorylation deoxycytidine or by kinase and deoxyadenosine has been studied. AraCTP was a potent inhibitor deoxyadenosine, but not deoxycytidine. inhibition produced araCTP appeared to be competitive with respect phosphate donor, ATP, for both kinase. measured in sonic extracts HeLa cells obtained from different phases cell cycle. rate increase significantly during S phase