Single vs Dual Vessel Porcine Extracorporeal Liver Perfusion

摘要: Abstract Background. The use of porcine extracorporeal liver perfusion (PECLP) to provide temporary hepatic support for patients in fulminant failure has been limited by the fact that individual perfusions can be sustained only a few hours. Inadequate function and/or hemodynamic instability are major contributing factors early interruption PECLP. Recent reports suggest choice single (portal vein only) vs dual and artery) vessel may influence duration perfusion. We hypothesize PECLP with (SVP) is associated worse greater than (DVP). Materials methods. To eliminate potentially confounding influences xenograft rejection, isografts procured from White-Landrace pig donors were perfused either SVP or DVP via an circuit established normal recipients. livers was evaluated measuring production bile Factors V VIII, clearance ammonia lactate, extraction O2 at baseline 0, 1, 3, 6, 12, 24 h after initiation impact on recipient status assessed monitoring BP, heart rate, urine output, saturation, etc. Among other parameters serum albumin total protein release IL-1β nitric oxide assess their possible contributions instability. Results. cleared lactate similarly. Both approaches progressive hypoalbuminemia hypoproteinemia. produced more Factor less hypotension NO livers. Conclusions. Livers better SVP. hypotension, although this complication severe