Neuroanatomical changes and hypothalamo-pituitary-adrenal axis abnormalities☆
作者： Vijaya P. Rao , K.Ranga Rama Krishnan , Veeraindar Goli , William B. Saunders , Everett H. Ellinwood
DOI: 10.1016/0006-3223(89)90108-X
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摘要: Hypothalamo-pituitary-adrenal (HPA) axis abnormalities are frequently observed in patients with major depression (Carroll 1982). The most extensively assessed abnormality is the early escape of cortisol from suppression after dexamethasone. Although this state dependent et al. 1976. 1981). its relationship to initiation and development depressive symptomatology remains an enigma. Ventricular enlargement cerebral atrophy also (Pearlson Veroff ventricular brain ratio (VBR) has been reported be correlated 24-hr urine-free (Kellner 1983). Targum (1983) did not find a between VBR Dexamethasone Suppression Test (DST), Rothschild (1988) recently statistically significant positive correlation highest postdexamethasone plasma concentrations. In earlier study
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