Roles of protein-tyrosine phosphatases in growth factor signalling☆
作者： Takashi Matozaki , Masato Kasuga
DOI: 10.1016/0898-6568(95)02015-2
关键词:
摘要: Abstract Protein-tyrosine phosphatases (PTPs) as well protein-tyrosine kinases play key roles in various growth factor-or cytokine-mediated signal transduction pathways. Some PTP directly dephosphorylates tyrosinephosphorylated factor receptors, whereas others mediate upstream signals to the downstream pathway a second messenger of stimulus. In addition, some functions negative feed-back growth-factor signalling. Since PTPs appear regulate factor-mediated cell proliferation both positive and manner, overexpression or loss certain types might contribute malignant transformation cells.
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