Cutting Edge: Proinflammatory and Th2 Cytokines Synergize to Induce Thymic Stromal Lymphopoietin Production by Human Skin Keratinocytes
作者： Sofia I. Bogiatzi , Isabel Fernandez , Jean-Christophe Bichet , Marie-Annick Marloie-Provost , Elisabetta Volpe
DOI: 10.4049/JIMMUNOL.178.6.3373
关键词:
摘要: Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine that strongly activates dendritic cells (DC) and can initiate allergic inflammation. The factors inducing the production of human TSLP are not known. In this study, we show proinflammatory (TNF-alpha or IL-1alpha) Th2 (IL-4 IL-13) cytokines synergized to induce in skin explants. situ was restricted epidermal keratinocytes suprabasal layer. could be inhibited by regulating inflammation, such as IL-10, TGF-beta, IFN-gamma. Cytokine-treated culture supernatants induced maturation blood CD11c(+) DC a TSLP-dependent manner. Our data provide first evidence induction subsequent activation skin. Blocking TSLP-inducing represent novel strategy for treatment diseases.
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