EXPERIENCE WITH A SIMPLE PROCEDURE FOR THE DETERMINATION OF PLASMA AND URINE FREE 11-HYDROXYCORTICOSTEROIDS.
作者： Clarence L. Gantt , Donald E. Maynard , George G. Hamwi
DOI: 10.1016/0026-0495(64)90152-0
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摘要: Abstract Plasma and urine free 11-hydroxycorticosteroids were measured by a simple fluorometric procedure. Precision recovery of cortisol excellent. The 8 to 9 a.m. mean plasma 11-hydroxycorticosteroid value was 17 ± 4.9 (S.D.) μg. 100 ml. agrees well with those reported using the Porter-Silber chromogen technic for measurements nonconjugated corticosteroids in normal subjects. Dexamethasone 2 mg. every 6 hours 24 resulted levels 2.2 ACTH 25 I.V. over hour period subjects gave 58.8 10.9 half-life injected 127 minutes is good agreement values other technics measure cortisol. urinary excretion 86.8 29.5 suppression did not lower this below range. day infusion rose 895 323 only one less than 470 . applied appears offer rapid measurement adrenal function that adequate most clinical purposes. Further studies are necessary judge findings.
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sci-hub.se 参考文章(19)
Nicolas Zenker, Donald E. Bernstein, The estimation of small amounts of corticosterone in rat plasma. Journal of Biological Chemistry. ,vol. 231, pp. 695- 701 ,(1958) , 10.1016/S0021-9258(18)70434-1
EVELINE J. ROY, J. B. BROWN, A METHOD FOR THE ESTIMATION OF OESTRIOL, OESTRONE AND OESTRADIOL-17β IN THE BLOOD OF THE PREGNANT WOMAN AND OF THE FOETUS Journal of Endocrinology. ,vol. 21, pp. 9- 23 ,(1960) , 10.1677/JOE.0.0210009
JEAN CRABBÉ, WILLIAM J. REDDY, ERIC J. ROSS, GEORGE W. THORN, The stimulation of aldosterone secretion by adrenocorticotropic hormone (ACTH). The Journal of Clinical Endocrinology and Metabolism. ,vol. 19, pp. 1185- 1191 ,(1959) , 10.1210/JCEM-19-10-1185
Ralph E. Peterson, James B. Wyngaarden, THE MISCIBLE POOL AND TURNOVER RATE OF HYDROCORTISONE IN MAN Journal of Clinical Investigation. ,vol. 35, pp. 552- 561 ,(1956) , 10.1172/JCI103308
R. E. Peterson, Aurora. Karrer, S. L. Guerra, Evaluation of Silber-Porter Procedure for Determination of Plasma Hydrocortisone Analytical Chemistry. ,vol. 29, pp. 144- 149 ,(1957) , 10.1021/AC60121A042
GERALD T. PERKOFF, CLINICAL USEFULNESS OF DETERMINATION OF CIRCULATING 17-HYDROXYCORTICOSTEROID LEVELS Archives of Internal Medicine. ,vol. 93, pp. 1- 8 ,(1954) , 10.1001/ARCHINTE.1954.00240250011001
C.P. Stewart, F. Albert-Recht, Laila M. Osman, The simultaneous fluorimetric microdetermination of cortisol and corticosterone in plasma Clinica Chimica Acta. ,vol. 6, pp. 696- 707 ,(1961) , 10.1016/0009-8981(61)90116-4
C. L. Cope, E. G. Black, Reliability of Some Adrenal Function Tests BMJ. ,vol. 2, pp. 1117- 1122 ,(1959) , 10.1136/BMJ.2.5160.1117
KRISTEN EIK-NES, AVERY A. SANDBERG, CLAUDE J. MIGEON, FRANK H. TYLER, LEO T. SAMUELS, CHANGES IN PLASMA LEVELS OF 17-HYDROXYCORTICOSTEROIDS DURING THE INTRAVENOUS ADMINISTRATION OF ACTH. II. RESPONSE UNDER VARIOUS CLINICAL CONDITIONS The Journal of Clinical Endocrinology and Metabolism. ,vol. 15, pp. 13- 21 ,(1955) , 10.1210/JCEM-15-1-13
Nicholas P. Christy, Eleanor Z. Wallace, Joseph W. Jailer, The Effect of Intravenously-Administered ACTH on Plasma 17, 21-Dihydroxy-20-Ketosteroids in Normal Individuals and in Patients with Disorders of the Adrenal Cortex Journal of Clinical Investigation. ,vol. 34, pp. 899- 906 ,(1955) , 10.1172/JCI103146