Adenosine Deaminase as a Biomarker of Tenofovir Mediated Inflammation in Naïve HIV Patients

摘要: Plasma levels of adenosine deaminase (ADA), an enzyme that deaminates to inosine, are increased during inflammation. An increase in ADA activity occurs with lower human immunodeficiency virus (HIV) viral load and higher CD4+ T cell counts. We aimed investigate the role plasma as a biomarker inflammation treatment-naive HIV patients who received tenofovir or another nucleoside analog for comparison. Ninety-two were included study grouped by treatment, i.e., disoproxil fumarate (TDF), alafenamide (TAF) Triumeq. was measured cytokines analyzed MILLIPLEX® MAP-Luminex® Technology. concentration monocytes neutrophils at 0, 3, 12 months post-treatment. Treatment-naive had concentrations (over 15 U/L) decreased after treatment TAF Triumeq, though this did not occur TDF-treated patients. However, all groups exhibited pro-inflammatory systemic profile treatment. GM-CSF TDF group, concomitant decrease blood monocyte count, negative correlation values found. In conclusion, may be modulated antiretroviral therapy patients, possibly affecting inflammatory status.