Abstract B62: Racial disparities in endometrial cancer incidence and mortality are limited to non-Hispanic black women

摘要: Background: Unlike the decreasing incidence seen for most cancers, rates of endometrial cancer have been increasing in United States over last decade. Earlier studies shown that mortality from are significantly higher non-Hispanic black women compared to white women, but this has not established other racial/ethnic groups. Our objective was determine whether and equally distributed by race/ethnicity tumor histologic subtype. Methods: Data Surveillance, Epidemiology End Results (SEER) registry were used identify diagnosed with 2000-2011. A total 120,513 including 90,621 (NHW) (75.2%), 11,386 Hispanic (9.4%), 10,365 (NHB) (8.6%) 8,141 Asian (6.8%) comprised study population. Age-adjusted incidence-based rates, 95% confidence intervals annual percent changes (APC), calculated (4 groups) overall 7 subtypes (low grade endometrioid, high clear cell, mixed, MMMT, serous, other), along rate ratios compare groups, using NHW as referent group. In addition, 5-year survival race/ethnic group, subtype, stage at diagnosis (localized, regional, distant). Differences between NHB percentage surviving 5 years described calculating (%NHW-%NHB)/%NHW) each subtype (21 comparisons). Results: Incidence cancers rising across all greatest change (APC) among (APC=2.5 both). Low-grade endometrioid commonly highest these stabilized or decreased decade exception (APC=1.0). High decade, particularly (APC=-2.5). aggressive (clear malignant mixed Mullerian tumors) women. had equal lower than subtypes. For every disease, is nearly comparison. The smallest difference localized where 6% survival, largest 59% distant cell cancers. same slightly better stages Conclusions: persist examined. Various factors, socioeconomic status (SES), comorbid conditions, access care, treatment decisions may impact disparity some extent, yet who many challenges risk occurrence outcomes similar after diagnosis. Additionally, types also more common rates. We fully account disparities primarily and, without intervention, they likely potentially widen emerges a significant cause morbidity decades come. Citation Format: Michele L. Cote, Julie J. Ruterbusch, Sara H. Olson, Karen Lu, Rouba Ali-Fehmi. Racial limited [abstract]. In: Proceedings Seventh AACR Conference on Science Health Disparities Racial/Ethnic Minorities Medically Underserved; Nov 9-12, 2014; San Antonio, TX. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2015;24(10 Suppl):Abstract nr B62.